Stem cells and the Planarian Schmidtea mediterranea
نویسندگان
چکیده
منابع مشابه
The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration.
Planarians have been used as a model to study development and regeneration for more than 200 years. Research on these animals has traditionally focused on surgical and pharmacological manipulations. Recently, the dissection of planarians has become more molecular in nature. The isolation of thousands of expressed sequence tags and the introduction of in situ hybridizations, immunocytology, and ...
متن کاملMulticellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea.
All multicellular organisms depend on stem cells for their survival and perpetuation. Their central role in reproductive, embryonic, and post-embryonic processes, combined with their wide phylogenetic distribution in both the plant and animal kingdoms intimates that the emergence of stem cells may have been a prerequisite in the evolution of multicellular organisms. We present an evolutionary p...
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In aquatic invertebrates, metabolic nitrogenous waste is excreted predominately as ammonia. Very little is known, however, of the underlying mechanisms of ammonia excretion, particularly in freshwater species. Our results indicate that in the non-parasitic freshwater planarian Schmidtea mediterranea, ammonia excretion depends on acidification of the apical unstirred layer of the body surface an...
متن کاملNeoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea
Planarians can regenerate any missing body part in a process requiring dividing cells called neoblasts. Historically, neoblasts have largely been considered a homogeneous stem cell population. Most studies, however, analyzed neoblasts at the population rather than the single-cell level, leaving the degree of heterogeneity in this population unresolved. We combined RNA sequencing of neoblasts fr...
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Mutations in Deleted in Azoospermia (DAZ), a Y chromosome gene, are an important cause of human male infertility. DAZ is found exclusively in primates, limiting functional studies of this gene to its homologs: boule, required for meiotic progression of germ cells in invertebrate model systems, and Daz-like (Dazl), required for early germ cell maintenance in vertebrates. Dazl is believed to have...
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ژورنال
عنوان ژورنال: Comptes Rendus Biologies
سال: 2007
ISSN: 1631-0691
DOI: 10.1016/j.crvi.2007.05.005